Cough & Cold Treatments
TL;DR
The ingredients found in a great deal of over the counter cough, cold and flu treatments are ineffective.
The ingredients you'll find in cough, cold and flu treatments, especially of the over the counter type, are often ineffective and unproven. Keep reading for a quick reference so you don't waste money or suffer needlessly, but first a quick explanation of the terms used;
- anaesthetic - reduces sensation including pain (temporarily)
- analgesic - reduces pain
- antipyretic - reduces fever
- antiseptic - reduces the possibility of sepsis, infection or putrefaction
- antitussive - reduces and/or suppresses coughing - should only be used by adults with dry coughs, not mucus producing ones
- decongestant - reduces or relieves nasal congestion (in the upper respiratory tract) - can cause high blood pressure
- expectorant - reduces mucus or sputum production or viscosity, or increases it's transportation (clearance from the airways)
- humectant - substances that keep things moist
Neither in this article but, as they are common remedies for a cold, please remember that children under 1 year old should not be given honey and children under 18 years old should not be given aspirin.
Effective Treatments
- Ibuprofen - analgesic
- Paracetamol/Tylenol - analgesic and antipyretic
- Phenylephrine - Spray Form - decongestant in spray form only
- Promethazine - reduces sneezing, runny nose and watery eyes
- Pseudoephedrine - effective oral decongestant not available over the counter (OTC)
- Amylmetacresol (AMC) - typically found in throat lozenges; a topical antiseptic and local anaesthetic used to treat mouth and throat infections and associated pain - effective but mild 1, 2
- Hexylresorcinol - as above
Ineffective Treatments
- Codeine - a claimed antitussive 3
- Dextromethorphan - another claimed antitussive 4
- Diphenhydramine - yet another claimed antitussive 4
- Glycerol/Glycerine - a claimed humectant
- Guaifenesin/Glyceryl Guaiacolate Ether (GGE) - a claimed expectorant and antitussive 5
- Phenylephrine - Tablet Form - a claimed decongestant which does not work if taken orally
References
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Weckmann G, Hauptmann-Voß A, Baumeister SE, Klötzer C, Chenot JF. Efficacy of AMC/DCBA lozenges for sore throat: A systematic review and meta-analysis. Int J Clin Pract. 2017 Oct;71(10). doi: 10.1111/ijcp.13002. Epub 2017 Sep 4. PMID: 28869700. ↩
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McNally D, Shephard A, Field E. Randomised, double-blind, placebo-controlled study of a single dose of an amylmetacresol/2,4-dichlorobenzyl alcohol plus lidocaine lozenge or a hexylresorcinol lozenge for the treatment of acute sore throat due to upper respiratory tract infection. J Pharm Pharm Sci. 2012;15(2):281-94. doi: 10.18433/j31309. PMID: 22579007. ↩
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Bolser DC, Davenport PW. Codeine and cough: an ineffective gold standard. Curr Opin Allergy Clin Immunol. 2007 Feb;7(1):32-6. doi: 10.1097/ACI.0b013e3280115145. PMID: 17218808; PMCID: PMC2921574. ↩
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Cough suppressants are ineffective in children. BMJ. 2004 Sep 18;329(7467):0. PMCID: PMC517624. ↩↩
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Hoffer-Schaefer A, Rozycki HJ, Yopp MA, Rubin BK. Guaifenesin has no effect on sputum volume or sputum properties in adolescents and adults with acute respiratory tract infections. Respir Care. 2014 May;59(5):631-6. doi: 10.4187/respcare.02640. Epub 2013 Sep 3. PMID: 24003241. ↩